24 June, 2022
Bacteriophages (Phages) are microorganisms that target and kill specific bacteria. Phage therapy is effectively used to treat and prevent bacterial infections (including antibiotic resistant infections) by killing harmful bacteria that cause illnesses, while at the same time not affecting beneficial bacteria and microbiome of the human body.. Substitution of irrational use of antibiotics, which fuels development of the resistance (bacteria becomes resistant to certain antibiotics) is one of the greatest challenges for the society and security in terms of the emerging global threat of antibiotic resistance. Phage therapy is the only viable alternative to antibiotic therapy nowadays. Using phage biodiversity and advanced technologies it is becoming increasingly accessible to discover new phages and develop highly effective bacteriophage based medicines, year by year. Dozens of phage preparations have commercially been and are available for more than 50 years.
Phage therapy has been successfully used to treat patients with severe, incurable infections as well as those who have developed resistance to antibiotics. A growing number of successful cases give patients, suffering from resistant infections, a hope that antibiotics can be replaced by alternative treatments such as bacteriophages. For decades, Phages have been the subject of intensive scientific investigation, which has led to astonishing results:
• Phages can be used successfully in patients whose antibiotic treatment has failed;
• Scientists have a large documentary material based on multiple investigations;
• Technological improvements have increased the number of phages that can be used to develop new medicines.
Phage therapy is a medical practice of applying bacteriophages and bacteriophage preparations for treatment and prevention of different chronic, severe infections caused by harmful (pathogenic) bacteria such as Staphylococcus (MRSA), E.Coli, Pseudomonas aeruginosa, Enterrococcus, Salmonella, Streptococcus (VRE), Proteus, Shigella, C. diff, Enterobacteriaceae, Acinetobacter and their combinations.Phage preparations are effectively used in medicine as a treatment for purulent-inflammatory infections, Bacterial infections of the upper and lower respiratory tract, gastrointestinal tract infections, in urology and infections of urogenital system, purulent-inflammatory neonatal infections, prosthetic joint infections and etc. caused by the above mentioned pathogenic bacteria. . Phages are also used to treat patients suffering from incurable multi-drug resistant infections.
Advantages of Phage therapy:
• Phages selectively target and destroy only the disease-causing bacteria, including antibiotic resistant ones;
• Unlike antibiotics, phages do not affect and damage beneficial microbiome of the human body;
• Phages are used for treatment as well as for prevention of life-threatening infections;
Phagyo® is a phage preparation and over the counter medicine that is one of the mostly used pharmaceutical product in Georgia and in the world of phage therapy. The phage preparation is produced by JSC BioChimPharm, the world leader in R&D and manufacturing of phage preparations with over 100 years of technological tradition and know-how.
Phagyo® used for treatment and prevention of bacterial purulent-inflammatory infections:
• Bacterial infections of the upper and lower respiratory tract (inflammation of the sinuses, otitis media, tonsillitis, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleuritis);
• gastroenterology (enterocolitis, cholecystitis, dysbiosis);
• in urology (urethritis, cystitis, pyelonephritis);
• purulent-inflammatory neonatal infections (omphalitis, pyoderma, conjunctivitis, sepsis);
Due to its unique natural characteristics, Phagyo® can be used in adults, children, newborn babies, during pregnancy and lactation, as well as in all vulnerable groups of patients. The medicine has no side effects, does not contain flavorings and colorings, the components of the medicine are not genetically modified organisms. This is what ensures Phagyo®s unprecedented level of safety for any antimicrobial. One 20 ml vial of the medicine contains over10 million specially selected phages, which determines its quality and effectiveness.
